Receptor Antogonist for Clinical Event Reduction in Acute Coronary Syndrome [TRACER] and Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events-Thrombolysis in Myocardial Infarction-50

Several factors influence the incidence and severity of cardiovascular disease, such as environmental exposures, medical adherence, and genetic polymorphisms. One of the genetic components is a heritable interindividual variation in platelet reactivity, which is greater in black individuals than whites. This correlates strongly with the historical observations that black individuals develop cardiovascular disease at a younger age and have a higher incidence of mortality from the disease. Platelet RNA And eXpression study (PRAX-1) was designed to identify the specific genetic components that correlate with variations in platelet reactivity. This study recently identified an expression profile of mRNAs and microRNAs that are associated with race and protease activated receptor 4 (PAR4) reactivity.